![]() ![]() ![]() Researchers now understand some of the gene changes that occur in different types of brain tumors, but it’s still not clear what causes most of these changes. A number of gene changes have been found in different brain tumor types, but there are probably many others that have not yet been found. There are many kinds of brain tumors, each of which may have different sets of gene changes. Several different gene changes usually occur in normal cells before they become cancerous. But the brain is relatively protected from most cancer-causing chemicals that we might breathe in or eat, so these factors are not likely to play a major role in these cancers. Most exposures that cause cancer, such as chemicals in tobacco smoke, somehow damage DNA. It's usually not known why people without inherited syndromes develop brain or spinal cord tumors. Gene changes acquired during a person's lifetime Changes in this gene increase the risk of developing brain tumors (particularly gliomas), as well as some other cancers. Normally, this gene prevents cells with damaged DNA from growing. For example, the Li-Fraumeni syndrome is caused by changes in the TP53 tumor suppressor gene. Researchers have found gene changes that cause some rare inherited syndromes (like neurofibromatosis, tuberous sclerosis, Li-Fraumeni syndrome, and von Hippel-Lindau syndrome) that increase the risk of developing some brain and spinal cord tumors. These gene changes can be inherited from a parent, but more often they happen during a person’s lifetime. ![]() Genes that help keep cell division under control, repair mistakes in DNA, or make cells die at the right time are called tumor suppressor genes.Ĭancers can be caused by DNA changes that turn on oncogenes or turn off tumor suppressor genes.Certain genes that help cells grow, divide, and stay alive are called oncogenes.Some genes control when our cells grow, divide into new cells, and die: We usually look like our parents because they are the source of our DNA. DNA is the chemical that makes up our genes, which control how our cells function. Brain and spinal cord tumors, like other tumors, are caused by changes in the DNA inside cells. Normal human cells grow and function based mainly on the information in each cell’s DNA. But researchers have found some of the changes that occur in normal brain cells that may lead them to form brain tumors. The cause of most brain and spinal cord tumors is not fully understood, and there are very few well-established risk factors. These different tumors are unlikely to all have the same causes, but they might share some things in common. Many different types of tumors can start in the brain or spinal cord. ![]()
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